Journal
MICRO & NANO LETTERS
Volume 14, Issue 5, Pages 470-474Publisher
INST ENGINEERING TECHNOLOGY-IET
DOI: 10.1049/mnl.2018.5557
Keywords
photothermal effects; nanomedicine; cellular biophysics; particle size; biomedical materials; radiation therapy; visible spectra; nanoparticles; ultraviolet spectra; gold; cancer; nanofabrication; tumours; Au; time 120; 0 s; wavelength 532; 0 nm; higher photothermal heating efficiency; breast cancer cells; photothermal killing; curcuma mangga; photothermal therapy; green synthesised-gold nanoparticles; cancer therapy; CM-AuNP-dependent photothermal-induced MCF-7 cells death; citrate-AuNPs; cell viability; laser irradiation; CM-AuNPs
Funding
- High Impact Research (HIR) MoE grant from the Ministry of Education, Malaysia [UM.C/625/1/HIR/MoE/SC/02]
- PPP from the University of Malaya [PG199-2014B]
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In this work, the use of gold nanoparticles (AuNPs), synthesised using Curcuma mangga (CM) extract in photothermal killing of breast cancer (MCF-7) cells is demonstrated. CM-AuNPs showed higher photothermal heating efficiency compared to citrate-AuNPs upon irradiation with a 532 nm laser. In addition, treatment of MCF-7 cells with CM-AuNPs coupled with laser irradiation for 120 s was found to significantly reduce (72%) the cell viability compared to about 13%, obtained with citrate-AuNPs. Results from flow cytometry showed that the CM-AuNP-dependent photothermal-induced MCF-7 cells death was triggered mainly by apoptosis mechanism. All these results suggested the potential use of CM-AuNPs as therapeutic agents in cancer therapy.
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