Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1848, Issue 10, Pages 2365-2373Publisher
ELSEVIER
DOI: 10.1016/j.bbamem.2015.07.008
Keywords
Protonectin; Antifungal; ROS production; Biofilm formation
Categories
Funding
- National Natural Science Foundation of China [31200584, 21272108, 21432003, 91213302, 81473095]
- Ministry of Science and Technology [2012ZX09504001-003]
- Research Fund for the Doctoral Program of Higher Education of China [20120211120045]
- Fundamental Research Funds for the Central Universities [lzujbky-2015-155]
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Candidiasis is often observed in immunocompromised patients and is the 4th most common cause of bloodstream infections. However, antifungals are limited, so novel antifungal agents are urgently needed. Antimicrobial peptides (AMPs) are considered as potential alternatives of conventional antibiotics. In the present study, antimicrobial peptide protonectin was chemically synthesized and its antifungal activity and mode of action were studied. Our results showed that protonectin has potent antifungal activity and fungicidal activity against the tested fungi cells. Its action mode involved the disruption of the membrane integrity and the inducing of the production of cellular ROS. Furthermore, protonectin could inhibit the formation of biofilm and kill the adherent fungi cells. In conclusion, with the increase of fungal infection, protonectin may offer a new strategy and be considered as a potential therapeutic agent against fungal disease. (c) 2015 Elsevier B.V. All rights reserved.
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