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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
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SCIENCE (2007)
Phase III study of oral compared with intravenous topotecan as second-line therapy in small-cell lung cancer
John R. Eckardt et al.
JOURNAL OF CLINICAL ONCOLOGY (2007)
Synthesis, DNA binding, and Leishmania topoisomerase inhibition activities of a novel series of anthra[1,2-d]imidazole-6,11-dione derivatives
Padmaparna Chaudhuri et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Inhibition of topoisomerase I cleavage activity by thiol-reactive compounds - Importance of vicinal cysteines 504 and 505
Daniele Montaudon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase i inhibition and cytotoxicity in human cancer cell cultures
Andrew Morrell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo
Min Huang et al.
CLINICAL CANCER RESEARCH (2007)
Total synthesis of luotonin A and 14-substituted analogues
Jeffrey J. Mason et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2007)
A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor
Andrew Morrell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles
Muthukaman Nagarajan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
The NCI60 human tumour cell line anticancer drug screen
Robert H. Shoemaker
NATURE REVIEWS CANCER (2006)
Topoisomerase I inhibitors: camptothecins and beyond
Yves Pommier
NATURE REVIEWS CANCER (2006)
The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant
Paola Fiorani et al.
NUCLEIC ACIDS RESEARCH (2006)
Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer
Ghassan K. Abou-Alfa et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors
Muthukaman Nagarajan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay
Andrew Morrell et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Synthesis and antitumor characterization of pyrazolic analogues of the marine pyrroloquinoline alkaloids: Wakayin and tsitsikammamines
Laurent Legentil et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
6-substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones:: Reversed lactam analogues of ARC-111 with potent topoisomerase 1-targeting activity and cytotoxicity
SJ Zhu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
The structure of the transition state of the heterodimeric topoisomerase I of Leishmania donovani as a vanadate complex with nicked DNA
DR Davies et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Total synthesis and biological evaluation of 22-hydroxyacuminatine
XS Xiao et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex
C Marchand et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Aza-analogues of the marine pyrroloquinoline alkaloids wakayin and tsitsikammamines: Synthesis and topoisomerase inhibition
L Legentil et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Topotecan is a substrate for multidrug resistance associated protein 4
Q Tian et al.
CURRENT DRUG METABOLISM (2006)
Esters and amides of 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine-12-carboxylic acid:: Potent cytotoxic and topoisomerase I-targeting agents
SJ Zhu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Effect of E-ring modifications in camptothecin on topoisomerase I inhibition: A quantum mechanics treatment
XS Xiao et al.
JOURNAL OF ORGANIC CHEMISTRY (2005)
DE-310, a macromolecular prodrug of the topoisomerase-I-inhibitor exatecan (DX-8951), in patients with operable solid tumors
MN Wente et al.
INVESTIGATIONAL NEW DRUGS (2005)
Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis
A Ioanoviciu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
An ab initio quantum mechanics calculation that correlates with ligand orientation and DNA cleavage site selectivity in camptothecin-DNA-topoisomerase I ternary cleavage complexes
XS Xiao et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Molecular determinants of topoisomerase I poisoning by lamellarins: Comparison with camptothecin and structure-activity relationships
E Marco et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Camptothecin and its analogues: a review on their chemotherapeutic potential
D Sriram et al.
NATURAL PRODUCT RESEARCH (2005)
Phase II trial of karenitecin in patients with relapsed or refractory non-small cell lung cancer (CALGB 30004)
AA Miller et al.
LUNG CANCER (2005)
On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex
XS Xiao et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Effect of the anticancer drug oracin on mouse liver topoisomerases I and II
S Stuchlík et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2005)
Synthesis and pharmacology of new camptothecin drugs
RW Driver et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2005)
Phase II trial of karenitecin in patients with malignant melanoma: Clinical and translational study
A Daud et al.
CLINICAL CANCER RESEARCH (2005)
Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11
MG Saulnier et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
BL Staker et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Syntheses and biological activities of rebeccamycin analogues with uncommon sugars
GS Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB
DA Koster et al.
NATURE (2005)
Synthesis of 14-azacamptothecin, a water-soluble topoisomerase I poison
NJ Rahier et al.
ORGANIC LETTERS (2005)
Phase II trial of oral rubitecan in previously treated pancreatic cancer patients
HA Burris et al.
ONCOLOGIST (2005)
5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones:: Variation of N-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance
AL Ruchelman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison
S Antony et al.
MOLECULAR PHARMACOLOGY (2005)
Camptothecin: current perspectives
CJ Thomas et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
A phase II study of liposomal lurtotecan (OSI-211) in patients with topotecan resistant ovarian cancer
MV Seiden et al.
GYNECOLOGIC ONCOLOGY (2004)
Regions within the N-terminal domain of human topoisomerase I exert important functions during strand rotation and DNA binding
RF Frohlich et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Topoisomerases of kinetoplastid parasites as potential chemotherapeutic targets
A Das et al.
TRENDS IN PARASITOLOGY (2004)
Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors
A Morrell et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
BN80927:: A novel homocamptothecin that inhibits proliferation of human tumor cells in vitro and in vivo
D Demarquay et al.
CANCER RESEARCH (2004)
Gimatecan, a novel camptothecin with a promising preclinical profile
G Pratesi et al.
ANTI-CANCER DRUGS (2004)
Role of the linker domain and the 203-214 N-terminal residues in the human topoisomerase I DNA complex dynamics
G Chillemi et al.
BIOPHYSICAL JOURNAL (2004)
Synthesis and topoisomerase I inhibitory properties of luotonin A analogues
A Cagir et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings
M Nagarajan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
A phase I study with MAG-camptothecin intravenously administered weekly for 3 weeks in a 4-week cycle in adult patients with solid tumours
FM Wachters et al.
BRITISH JOURNAL OF CANCER (2004)
Phase I and pharmacokinetic study of XR11576, an oral topoisomerase I and II inhibitor, administered on days 1-5 of a 3-weekly cycle in patients with advanced solid tumours
MJA de Jonge et al.
BRITISH JOURNAL OF CANCER (2004)
Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)
Anita K. Lalloo et al.
BMC MEDICINE (2004)
Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors
XS Xiao et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
Synthesis and biochemical properties of E-ring modified luotonin A derivatives
A Cagir et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen
M Nagarajan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Synthesis of new 3-arylisoquinolinamines: Effect on topoisomerase I inhibition and cytotoxicity
WJ Cho et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Luotonin A. A naturally occurring human DNA topoisomerase I poison
A Cagir et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6] naphthyridin-6-ones and related compounds as TOP1-targeting agents:: Influence of structure on the ternary cleavable complex formation
JE Kerrigan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions
I Plo et al.
DNA REPAIR (2003)
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-Camptothecin hybrids
BM Fox et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosis
C Zhao et al.
CANCER (2003)
An unusual type IB topoisomerase from African trypanosomes
AL Bodley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones:: Effect on topoisomerase-1 targeting activity and cytotoxicity
SK Singh et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
5H-Dibenzo[c,h]1,6-naphthyridin-6-ones:: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity
AL Ruchelman et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agents
D Makhey et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Substituted dibenzo[c,h]cinnolines:: Topoisomerase I-targeting anticancer agents
YN Yu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
A novel active DNA topoisomerase I in Leishmania donovani
H Villa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Rebeccamycin analogues as anti-cancer agents
M Prudhomme
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2003)
The mechanism of topoisomerase I poisoning by a camptothecin analog
BL Staker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Diaza- and triazachrysenes: Potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435
AL Ruchelman et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)
PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
ST Yang et al.
NATURE CELL BIOLOGY (2002)
DNA binding and topoisomerase I poisoning activities of novel disaccharide indolocarbazoles
M Facompre et al.
MOLECULAR PHARMACOLOGY (2002)
Inactivation of NF-κB-dependent cell survival, a novel mechanism for the proapoptotic function of c-abl
H Kawai et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Novel angular benzophenazines: Dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents
N Vicker et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II
P Mistry et al.
ANTI-CANCER DRUGS (2002)
Design and optimization of 20-O-linked camptothecin glycoconjugates as anticancer agents
HG Lerchen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
9-Nitrocamptothecin inhibits HIV-1 replication in human peripheral blood lymphocytes: A potential alternative for HIV-Infection/AIDS therapy
CL Hung et al.
JOURNAL OF MEDICAL VIROLOGY (2001)
A type IB topoisomerase with DNA repair activities
GI Belova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells
RG Shao et al.
ONCOGENE (2001)
Antitumor activity of XR5944, a novel and potent topoisomerase poison
AJ Stewart et al.
ANTI-CANCER DRUGS (2001)
Apoptotic response of HL-60 human leukemia cells to the antitumor drug NB-506, a glycosylated indolocarbazole inhibitor of topoisomerase 1
M Facompre et al.
BIOCHEMICAL PHARMACOLOGY (2001)
A novel nuclear localization signal in human DNA topoisomerase I
YY Mo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity
D Bom et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Synthesis of new indeno[1,2-c]isoquinolines:: Cytotoxic non-camptothecin topoisomerase I inhibitors
M Cushman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Positive and negative regulation of apoptotic pathways by cytotoxic agents in hematological malignancies
E Solary et al.
LEUKEMIA (2000)
Essential functions of DNA topoisomerase I in Drosophila melanogaster
CX Zhang et al.
DEVELOPMENTAL BIOLOGY (2000)
Conversion of topoisomerase 1 cleavage complexes on the leading strand of ribosomal DNA into 5′-phosphorylated DNA double-strand breaks by replication runoff
D Strumberg et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Checkpoints: How to activate p53
T Caspari
CURRENT BIOLOGY (2000)
Bis(phenazine-1-carboxamides): Structure-activity relationships for a new class of dual topoisomerase I/II-directed anticancer drugs
JA Spicer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons
D Makhey et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2000)
Synthesis and biological activities of NB-506 analogues modified at the glucose group
M Ohkubo et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2000)
Novel human topoisomerase I inhibitors, topopyrones A, B, C and D - I. Producing strain, fermentation, isolation, physico-chemical properties and biological activity
Y Kanai et al.
JOURNAL OF ANTIBIOTICS (2000)
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