Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 27, Issue 11-12, Pages 2530-2537Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-018-2255-0
Keywords
Benzylidene imidazolone; P-porphyrin; Intermolecular electron transfer; Fluorescent probe
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Funding
- Japan Society for the Promotion of Science (JSPS) [16K05847]
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Tetraphenylporphyrinatophosphorus(V) complexes (1) comprising two axially linked benzylidene imidazolone (Biz) moieties, which are chromophores of the green fluorescent protein, were prepared. In medical applications such as photodynamic therapy, the P-porphyrin part (Ptp) is expected to sensitize to generate singlet oxygen, whereas the Biz units act as fluorescent probes. The fluorescence spectra of 1 were analyzed under the excitations of Biz at 370nm. Fluorescence stemming from the excited states of Biz and Ptp was observed at 460 and 610nm, respectively. The intramolecular quenching of Biz in the excited singlet state by Ptp occurred, resulting in weak fluorescence from Biz. The introduction of a cyano group in the Biz units of 1 enhanced their fluorescence quantum yield up to 7.7x10(-4). The fluorescence spectra of 1 under the excitations of Ptp at 550nm were extremely similar to that of a reference compound of P-porphyrin without the Biz chromophore, dimethoxy(tetraphenylporphyrinato)phosphorus chloride. The physicochemical parameters of Ptp remained unaltered following the introduction of Biz on the axial positions of P-porphyrin.
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