Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 18, Pages 11210-11214Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b02965
Keywords
bowl-like; microcapsules; polyelectrolyte; shape effect; cellular uptake; osmotic pressure
Funding
- Natural Science Foundation of China [21374101, 51120135001]
- Key Science Technology Innovation Team of Zhejiang Province [2013TD02]
- Fundamental Research Funds for the Central Universities [2016QNA4033]
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Among several properties of colloidal particles, shape is emerging as an important parameter for tailoring the interactions between particles and cells. In this study, bowl-like multilayer microcapsules were prepared by osmotic-induced invagination of their spherical counterparts in a concentrated polyelectrolyte solution. The internalization behaviors of bowl-like and spherical microcapsules were compared by coincubation with smooth muscle cells (SMCs) and macrophages. The bowl-like capsules tended to attach onto the cell membranes from the bend side and could be enwrapped by the membranes of SMCs, leading to a faster uptake rate and larger accumulation inside cells than those of their spherical counterparts. These results are important for understanding the shape-dependent internalization behavior, providing useful guidance for further materials design especially in biomedical applications.
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