Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 24, Pages 15076-15085Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b03262
Keywords
multifunctional fluorescent-magnetic nanoprobes; multicolor fluorescence nanodots; heterogeneous circulating tumor cell capturing; mapping of epithelial; mesenchymal; stem nanodots; cells simultaneously
Funding
- NSF-PREM [DMR-1205194]
- NIH [G12MD007581]
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Circulating tumor cells (CTC) are highly heterogeneous in nature due to epithelial mesenchymal transition (EMT), which is the major obstacle for CTC analysis-via liquid biopsy. This article reports the development of a new class of multifunctional fluorescent magnetic multicolor nanoprobes for targeted capturing and accurate identification of heterogeneous CTC. A facile design approach for the synthesis and characterization of bioconjugated multifunctonal nanoprobes that exhibit excellent magnetic properties and emit very bright and photostable multicolor fluorescence at red, green, and blue under 380 nm excitation is reported. Experimental data presented show that the multifunctional multicolor nanoprobes can be used for targeted capture and multicolor fluorescence mapping of heterogeneous CTC and can distinguish targeted CTC from nontargeted cells.
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