Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 28, Pages 17936-17943Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b05795
Keywords
chlorophyll; self-assembly; dynamic equilibrium; caspase-1; bacterial infection
Funding
- National Basic Research Program of China (973 Program) [2013CB932701]
- National Natural Science Foundation of China [21374026, 21304023, 21506161, 51303036]
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In situ construction of self-assemblies with unique property in living systems is a promising direction in the biomedical field. The noninvasive methods for significant enzyme activity in living cells or living subjects are imperative and meantime challenge tasks. The dynamic process of self-assembly of chlorophyll-based molecules in complex biological systems can be monitored by photoacoustic signals, which supports a noninvasive way to understand and quantitatively measure the activity of caspase-1. Furthermore, the activity of caspase-1 enables reflection of the bacterial infection in the early stage. Here, we present a biocompatible self-assembly from chlorophyll peptide derivatives and first correlate the dynamic equilibrium with ratiometric photoacoustic signals. The intracellular equilibrium was managed by a bacterial infection precaution protein, i.e., caspase-1. This system offers a trial of noninvasive method to quantitative detection and real-time monitoring of bacterial infection in the early stage.
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