Journal
MEDICAL MYCOLOGY
Volume 57, Issue 8, Pages 954-961Publisher
OXFORD UNIV PRESS
DOI: 10.1093/mmy/myy163
Keywords
sporotrichosis; Sporothrix schenckii; Sporothrix globosa; molecular identification; yeast phase; antifungal susceptibility; China
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Funding
- National Natural Science Foundation of China [31600120]
- Science and Technology Support Program of Nanchang, China [2016-ZCJHSF-092]
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Sporotrichosis is a subcutaneous mycosis caused by traumatic inoculation of pathogenic Sporothrix species. Until recently, Sporothrix globosa was considered as the unique Chinese species causing this disorder. In the present study, 33 clinical Sporothrix strains isolated from Jiangxi, China, were classified and antifungal susceptibility for each strain was determined. Thirteen S. globosa strains and 20 S. schenckii strains were identified by morphology and by multilocus analysis using rDNA ITS, CAL, and EF1 alpha (i.e., internal transcribed spacer, calmodulin and elongation factor-1 alpha). In vitro antifungal susceptibility testing of yeast phases indicated that itraconazole, terbinafine, and posaconazole were most effective against both species, followed by amphotericin B and voriconazole, while fluconazole, 5-fluorocytosine had low efficacy with high MICs. Co-occurrence of S. schenckii and S. globosa in central China may indicate different routes of transmission in this area.
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