Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 27, Pages 17118-17126Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b04424
Keywords
silk; hydrogel; thixothopic; drug delivery; injectable
Funding
- National Basic Research Program of China (973 Program) [2013CB934400]
- NSFC [21174097, 51403144]
- NIH [R01 DE017207]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Excellent Youth Foundation of Jiangsu Province [BK2012009]
- Natural Science Foundation of Jiangsu Province [BK20140397, BK20140401]
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Silk is useful as a drug carrier due to its biocompatibility, tunable degradation, and outstanding capacity in maintaining the function of drugs. Injectable silk hydrogels could deliver doxorubicin (DOX) for localized chemotherapy for breast cancer. To improve hydrogel properties, thixotropic silk nanofiber hydrogels in an all aqueous solution were prepared and used to locally deliver DOX. The silk hydrogels displayed thixotropic capacity, allowing for easy injectability followed by solidification in situ. The hydrogels were loaded with DOX and released the drug over eight weeks with pH- and concentration-dependent release kinetics. In vitro and in vivo studies demonstrated that DOX-loaded silk hydrogels had good antitumor response, outperforming the equivalent dose of free DOX administered intravenously. Thixotropic silk hydrogels provide improved injectability to support sustained release, suggesting promising applications for localized chemotherapy.
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