Journal
MATURITAS
Volume 119, Issue -, Pages 25-38Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.maturitas.2018.11.002
Keywords
Probiotics; Lactic acid bacteria; Symbiosis; Dysbiosis; Gastrointestinal tract; Inflammatory bowel disease
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As a person ages, physiological, immunological and gut microbiome changes collectively result in an array of chronic conditions. According to the 'hygiene hypothesis' the increasing prevalence of immune-mediated disorders may be related to intestinal dysbiosis, leading to immune dysfunction and associated conditions such as eczema, asthma, allergies and autoimmune diseases. Beneficial probiotic bacteria can be utilized by increasing their abundance within the gastrointestinal lumen, which in turn will modulate immune cells, such as, T helper (Th)-1, Th2, Th17, regulatory T (Treg) cells and B cells, which have direct relevance to human health and the pathogenesis of immune disorders. Here, we describe the cross-talk between probiotics and the gastrointestinal immune system, and their effects in relation to inflammatory bowel disease, multiple sclerosis, allergies and atopic dermatitis.
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