Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 11, Pages 6826-6833Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b12833
Keywords
aptasensor; molybdenum disulfide; gold nanoparticles; simultaneous detection; logic gates
Funding
- National Basic Research Program of China [2012CB933301]
- National Natural Science Foundation of China [21305070, 21475064]
- Natural Science Foundation of Jiangsu Province [BK20130861]
- Sci-tech Support Plan of Jiangsu Province [BE2014719]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_15R37]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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A MoS2-based electrochemical aptasensor has been developed for the simultaneous detection of thrombin and adenosine triphosphate (ATP) based on gold nano particles-decorated MoS2 (AuNPs-MoS2) nanocomposites. Two different aptamer probes labeled with redox tags were simultaneously immobilized on an AuNPs-MoS2 film modified electrode via Au-S bonds. The aptamers presented structural switches with the addition of target molecules (thrombin and ATP), resulting in methylene blue (MB) far from or ferrocene (Fc) close to the electrode surface. Therefore, a dual signaling detection strategy was developed, which featured both signal-on and signal-off' elements in the detection system because of the target-induced structure switching. This proposed aptasensor could simultaneously determine ATP and thrombin as low as 0.74 nM ATP and 0.0012 nM thrombin with high selectivity, respectively. In addition, thrombin and ATP could act as inputs to activate an AND logic gate.
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