Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 94, Issue -, Pages 220-233Publisher
ELSEVIER
DOI: 10.1016/j.msec.2018.09.022
Keywords
Drug nanocarrier; Phthalocyanine; Photosensitizer; Biodegradable polymer; Amphiphilic block copolymer; Field flow fractionation
Categories
Funding
- Sao Paulo Research Foundation (FAPESP, Brazil) [2014/50928-2]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil) [465687/2014-8]
- CNPq [BJT 400889/2014-5, 310463/2015-7, 481872/2013-2]
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais [FAPEMIG APQ-02864-16]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- NANOBIOMG Network Minas Gerais [RED-00007-14]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [14/50928-2] Funding Source: FAPESP
Ask authors/readers for more resources
For best photosensitizer activity phthalocyanine dyes used in photodynamic therapy should be molecularly dispersed. Polyethylene glycol-block-polylactide derivatives presenting benzyl side-groups were synthesized to encapsulate a highly lipophilic phthalocyanine dye (AlClPc) and evaluate the effect of pi-pi interactions on the nanocarrier colloidal stability and dye dispersion. Copolymers with 0, 1, 2 and 6 mol% of benzyl glycidyl ether (BGE) were obtained via polyethylene glycol initiated ring-opening copolymerization of D,L-lactide with BGE. The block copolymers formed stable, monodisperse nanospheres with low in vitro cytotoxicity. AlClPc loading increased the nanosphere size and affected their colloidal stability. The photo-physical properties of the encapsulated dye, studied in batch and after separation by field flow fractionation, demonstrated the superiority of plain PEG-PLA over BGE-containing copolymers in maintaining the dye in its monomeric (non-aggregated) form in aqueous suspension. High dye encapsulation and sustained dye release suggest that these nanocarriers are good candidates for photodynamic therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available