Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 2, Pages 1080-1086Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b11445
Keywords
microfiber; tissue engineering; cell-encapsulation; microfluidics; hydrogel
Funding
- National Science Foundation of China [21473029, 91227124, 51522302]
- NASF Foundation of China [U1530260]
- National Science Foundation of Jiangsu [BK20140028]
- research Fund for the Doctoral Program of Higher Education of China [20120092130006]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1222]
- Program for New Century Excellent Talents in University
Ask authors/readers for more resources
The fabrication of heterogeneous microstructures, which exert precise control over the distribution of different cell types within biocompatible constructs, is important for many tissue engineering applications. Here, bioactive microfibers with tunable morphologies, structures, and components are generated and employed for creating different tissue constructs. Multibarrel capillary microfluidics with multiple laminar flows are used for continuously spinning these microfibers. With an immediate gelation reaction of the cell dispersed alginate solutions, the cell-laden alginate microfibers with the tunable morphologies and structures as the designed multiple laminar flows can be generated. The performances of the microfibers in cell culture are improved by incorporating bioactive polymers, such as extracellular matrix (ECM) or methacrylated gelatin (GelMA), into the alginate. It is demonstrated that a series of complex three-dimensional (3D) architectural cellular buildings, including biomimic vessels and scaffolds, can be created using these bioactive microfibers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available