Journal
MASS SPECTROMETRY REVIEWS
Volume 38, Issue 3, Pages 253-264Publisher
WILEY
DOI: 10.1002/mas.21581
Keywords
peptidomics; biofluids; mass spectrometry; extraction; identification; neuropeptide
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Naturally occurring peptides, including growth factors, hormones, and neurotransmitters, represent an important class of biomolecules and have crucial roles in human physiology. The study of these peptides in clinical samples is therefore as relevant as ever. Compared to more routine proteomics applications in clinical research, peptidomics research questions are more challenging and have special requirements with regard to sample handling, experimental design, and bioinformatics. In this review, we describe the issues that confront peptidomics in a clinical context. After these hurdles are (partially) overcome, peptidomics will be ready for a successful translation into medical practice.
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