Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1848, Issue 10, Pages 2493-2501Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2015.04.013
Keywords
voltage-gated sodium channel; metastasis; migration; invasion; cancer; lipid raft
Categories
Funding
- Ministere de la Recherche et des Technologies
- Inserm
- Universite Francois Rabelais de Tours
- Ligue Nationale Contre le Cancer
- Region Centre (NaVMetarget)
- Region Centre (LIPIDS) [ARD2020-Biomedicaments]
- Association CANCEN
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Voltage-gated sodium channels are abnormally expressed in tumors, often as neonatal isoforms, while they are not expressed, or only at a low level, in the matching normal tissue. The level of their expression and their activity is related to the aggressiveness of the disease and to the formation of metastases. A vast knowledge on the regulation of their expression and functioning has been accumulated in normal excitable cells. This helped understand their regulation in cancer cells. However, how voltage-gated sodium channels impose a pro-metastatic behavior to cancer cells is much less documented. This aspect will be addressed in the review. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers. (C) 2015 Elsevier B.V. All rights reserved.
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