Journal
MARINE DRUGS
Volume 17, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/md17010041
Keywords
injectable drug delivery depot system; visible light-cured glycol chitosan hydrogel; beta-cyclodextrin; paclitaxel; ovarian cancer therapy
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Funding
- Technology Innovation Program - Ministry of Trade, Industry, and Energy (MOTIE, Republic of Korea) [10053595]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) [2014R1A1A1002697, 2017R1D1A1B03033195, 2018R1A2B6009283, 2018R1D1A3B07048343, 201701410002]
- National Research Foundation of Korea [2014R1A1A1002697, 2018R1D1A3B07048343, 2018R1A2B6009283] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In this study, we prepared an injectable drug delivery depot system based on a visible light-cured glycol chitosan (GC) hydrogel containing paclitaxel (PTX)-complexed beta-cyclodextrin (-CD) (GC/CD/PTX) for ovarian cancer (OC) therapy using a tumor-bearing mouse model. The hydrogel depot system had a 23.8 Pa of storage modulus at 100 rad/s after visible light irradiation for 10 s. In addition, GC was swollen as a function of time. However, GC had no degradation with the time change. Eventually, the swollen GC matrix affected the releases of PTX and CD/PTX. GC/PTX and GC/CD/PTX exhibited a controlled release of PTX for 7 days. In addition, GC/CD/PTX had a rapid PTX release for 7 days due to improved water solubility of PTX through CD/PTX complex. In vitro cell viability tests showed that GC/CD/PTX had a lower cell viability percentage than the free PTX solution and GC/PTX. Additionally, GC/CD/PTX resulted in a superior antitumor effect against OC. Consequently, we suggest that the GC/CD system might have clinical potential for OC therapy by improving the water solubility of PTX, as PTX is included into the cavity of beta-CD.
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