Journal
MARINE DRUGS
Volume 16, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/md16110428
Keywords
Aspergillus terreus Y10; asperteretal F; G(1); G(2); H; open-ring butenolide; microglial; anti-neuroinflammatory activity
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Funding
- National Natural Science Foundation of China [81773600]
- Scientific Research Foundation of the Third Institute of Oceanography, SOA [2015004]
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To investigate structurally novel and anti-neuroinflammatory natural compounds from marine-derived microorganisms, the secondary metabolites of Aspergillus terreus Y10, a fungus separated from the sediment of the coast in the South China Sea, were studied. Three new compounds (2-4), with novel open-ring butenolide skeletons, were isolated from the ethyl acetate extract of the culture medium. In addition, a typical new butenolide, asperteretal F (1), was found to dose-dependently inhibit tumor necrosis factor (TNF-) generation with an IC50 of 7.6 g/mL. The present study shows the existence of open-ring butenolides, and suggests that butenolides such as asperteretal F (1) are a promising new anti-neuroinflammatroy candidate for neurodegenerative diseases.
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