Journal
MARINE DRUGS
Volume 16, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/md16120513
Keywords
sceptrin; pyrrole-imidazole alkaloids; marine sponge; anti-angiogenesis; isocitrate lyase; bioactive marine natural products
Categories
Funding
- BK21 Plus program in 2018, the Ministry of Oceans and Fisheries, Korea [PM 58482]
- National Research Foundation (NRF) - Ministry of Science, ICT & Future Planning, Korea [2018R1A4A1021703]
Ask authors/readers for more resources
Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of -amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available