Journal
MARINE DRUGS
Volume 16, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/md16100390
Keywords
biological invasion; Caulerpa cylindracea; secondary metabolites; Diplodus sargus; metabolomics; NMR spectroscopy
Categories
Funding
- PON (Programma Operativo Nazionale) Ricerca. Potenziamento del Centro Ricerche per la Salute dell'Uomo e dell'Ambiente [PONa3_00334, 254]
- MIUR (Ministry of Education, Universities and Research) (PRIN 2009, CAUDIP project)
- MIUR (Ministry of Education, Universities and Research) (PRIN 2012, CAULERFISH project)
- EU FP7 PERSEUS Project [287600]
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The biological invasion of the green algae Caulerpa cylindracea represents a serious scientific and public issue in the Mediterranean Sea, essentially due to strong modifications both to habitat structure and native benthic communities. Although alterations in health status and changes in flesh quality of some marine species (dietary exposed to C. cylindracea) have been observed, no studies on cause-effect relationships have been carried out. Here, for the first time, through a controlled feeding experiment followed by H-1 NMR Spectroscopy and multivariate analysis (PCA, OPLS-DA), we showed that caulerpin taken with diet is directly responsible of changes observed in metabolic profile of fish flesh, including alteration of lipid metabolism, in particular with a reduction of 3 PUFA content. The potential of caulerpin to directly modulate lipid metabolism opens up new questions about causal mechanism triggered by algal metabolite also in view of a possible exploitation in the nutraceutical/medical field.
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