Journal
MARINE DRUGS
Volume 16, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/md16100363
Keywords
endophytic fungus; Myrothecium sp; meroterpenoids; isocoumarinoids; -glucosidase inhibitors; salt-resistant plant; Apocynum venetum
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Funding
- National Natural Science Foundation of China [81561148012, U1501221, 81741150, U1606403] Funding Source: Medline
- the 100 Leading Talents of Guizhou Province [for W. Zhu] Funding Source: Medline
- the science and technology project of Guizhou [QKHT Z-2014-4007] Funding Source: Medline
- the academician workstation of Guizhou [QKH YSZ-2015-4009] Funding Source: Medline
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Four new meroterpenoids 1-4 and four new isocoumarinoids 5-8, along with five known isocoumarinoids (9-13), were isolated from the fungus Myrothecium sp. OUCMDZ-2784 associated with the salt-resistant medicinal plant, Apocynum venetum (Apocynaceae). Their structures were elucidated by means of spectroscopic analysis, X-ray crystallography, ECD spectra and quantum chemical calculations. Compounds 1-5, 7, 9 and 10 showed weak -glucosidase inhibition with the IC50 values of 0.50, 0.66, 0.058, 0.20, 0.32, 0.036, 0.026 and 0.37 mM, respectively.
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