Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 35, Pages 22942-22952Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b07997
Keywords
Fe3O4 nanoparticle; polydopamine; self-assembly; superparticle; theranostics
Funding
- NSFC [51425303, 21374042, 81320108011, 81271111]
- 973 Program of China [2014CB643503]
- Natural Science Foundation of Jilin Province [20140101048JC]
- MOST of China
- Fundamental Research Funds for the Central Universities
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Iron oxide (Fe3O4), polydopamine (PDA), and in particular their composites are examples of the safest nanomaterials for developing multifunctional nanodevices to perform noninvasive tumor diagnosis and therapy. However, the structures and performances of Fe3O4-PDA nano composites should be further perfected to enhance the theranostic efficiency. In this work, we demonstrate the fabrication of PDA-capped Fe3O4 (Fe3O4@PDA) super particles (SPs) employing preassembled Fe3O4 nanoparticles (NPs) as the cores. Owing to the collective effect of preassembled Fe3O4 NPs, the superparamagnetism and photothermal performance of Fe3O4@PDA SPs are greatly enhanced, thus producing nanodevices with improved magnetic resonance imaging (MRI)-guided photothermal efficiency. Systematical studies reveal that the molar extinction coefficient of the as-assembled Fe3O4 SPs is 3 orders of magnitude higher than that of individual Fe3O4 NPs. Also due to the high aggregation degree of Fe3O4 NPs, the T-2-weighted MRI contrast is greatly enhanced for the SPs with r(2) relaxivity of 230.5 mM(-1) s(-1), which is similar to 2.5 times larger than that of individual Fe3O4 NPs. The photothermal stability, physiological stability, and biocompatibility, as well as the photothermal performance of Fe3O4 SPs, are further improved by enveloping with PDA shell.
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