Journal
MARINE BIOTECHNOLOGY
Volume 21, Issue 1, Pages 88-98Publisher
SPRINGER
DOI: 10.1007/s10126-018-9861-1
Keywords
Butenolide; Antibiofilm agent; Antibiotics enhancer; Drug discovery
Funding
- Open Financial Grant from Qingdao National Laboratory for Marine Science and Technology [QNLM2016ORP0302]
- National Natural Science Foundation of China [41376145, 41706155]
- Scientific and Technical Innovation Council of Shenzhen [KQJSCX20170330110206042]
- Foundation for Distinguished Young Talents in Higher Education of Guangdong, China [2014KQNCX126]
- China Postdoctoral Science Foundation [2017M622754]
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Bacterial biofilm can cause nosocomial recurrent infections and implanted device secondary infections in patients and strongly promotes development of pathogenic drug resistance in clinical treatments. Butenolide is an effective anti-macrofouling compound derived from a marine Streptomyces sp., but its antibiofilm efficacy remains largely unexplored. In the present study, the antibiofilm activities of butenolide were examined using biofilms formed by both Gram-positive and Gram-negative pathogenic model species. Four Escherichia coli strains, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus (MRSA) were used as targets in antibiofilm assays that examined the effects of butenolide, including the following: (i) on bacterial growth; (ii) in inhibiting biofilm formation and eradicating mature biofilm; (iii) on biofilm structures. In addition, the synergistic effect between butenolide with tetracycline was also examined. Butenolide not only effectively inhibited the biofilm formation but also eradicated pre-formed biofilms of tested bacteria. Fractional inhibitory concentration index (FICI) indicated that butenolide was a potential tetracycline enhancer against E. coli, P. aeruginosa, and MRSA. These results indicated that butenolide may hold a great potential as an effective antibiofilm agent to control and prevent biofilm-associated infections in future clinical treatments.
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