Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 46, Pages 31567-31573Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b10916
Keywords
ce-MoS2; surface functionalization; antibiotics; ESKAPE pathogens; nanomaterials; membrane depolarization; oxidative stress
Funding
- Department of Science and Technology (DST, Government of India)
- Council for Scientific and Industrial Research (CSIR, Government of India)
- Department of Biotechnology (DBT, Government of India) through the center of excellence project: Translational Center on Biomaterials for Orthopedic and Dental Applications
- DST
- DST-INSPIRE
- CSIR
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In view of the implications of inherent resistance of pathogenic bacteria, especially ESKAPE pathogens toward most of the commercially available antibiotics and the importance of these bacteria-induced biofilrn formation leading to chronic infection, it is important to develop new generation synthetic materials with greater efficacy toward antibacterial property. In addressing this issue, this paper reports a proof-of-principle study to evaluate the potential of functionalized two-dimensional chemically exfoliated MoS2 (ce-MoS2) toward inhibitory and bactericidal property against two representative ESKAPE pathogenic strain a Gram-positive Staphylococcus aureus (MRSA) and a Gram-negative Pseudomonas aeruginosa. More significantly, the mechanistic study establishes a different extent of oxidative stress together with rapid membrane depolarization in contact with ce-MoS2 having ligands of varied charge and hydrophobicity. The implication of our results is discussed in the light of the lack of survivability of planktonic bacteria and biofilm destruction in vitro. A comparison with widely used small molecules and other nanomaterial-based therapeutics conclusively establishes a better efficacy of 2D ce-MoS2 as a new class of antibiotics.
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