Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 27, Pages 17047-17059Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b02936
Keywords
star-shaped polymer; fluorescence; near infrared; two photon absorption; intravital microscopy; TD-DFT
Funding
- French program Investissement d'Avenir
- grant Infrastructure d'avenir en Biologie Sante [ANR11-INBS-0006]
- CPER, region Rhone-Alpes
- IBiSA-ISdV
- Iuventus Plus grant [IP2012 004172]
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A chromophore-engineering strategy that relies on the introduction of a ground-state distortion in a quadrupolar chromophore was used to obtain a quasi-quadrupolar chromophore with red emission and large two-photon absorption (2PA) cross-section in polar solvents. This molecule was functionalized with water-solubilizing polymer chains. It constitutes not only a remarkable contrast agent for intravital two-photon microscopy of the functional cerebral vasculature in a minimally invasive configuration but presents intriguing endothelial staining ability that makes it a valuable probe for premortem histological staining.
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