Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 40, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201800541
Keywords
click reactions; crosslinking; drug delivery; nanocarriers
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Funding
- National Natural Science Foundation of China [51703209, 21603196]
- Natural Science Foundation of Hubei Province [2017CFB217]
- Fundamental Research Funds for the Central Universities, China University of Geosciences (Wuhan) [CUG170601, CUGL170406]
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Click-crosslinking has been widely used for the fabrication of nanocarriers in recent years. Crosslinking can enhance the stability of nanocarriers that have served as an emerging platform for drug delivery to achieve cancer diagnosis and therapy. In crosslinking methods, click reactions have attracted increasing attention owing to their high reaction specificity and physiologically stable products. These reports on click-crosslinked nanocarriers are divided into four sections (nanogels, nanoparticles, micelles, and capsules) according to the types of nanocarriers. Click-crosslinked nanocarriers enhance the solubility of hydrophobic drugs and improve the efficacy of drug delivery owing to their good stability. Stimuli-responsive and targeted strategies can be introduced into click-crosslinked nanocarriers to enhance drug accumulation in tumors.
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