Journal
MACROMOLECULAR BIOSCIENCE
Volume 19, Issue 1, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201800281
Keywords
drug delivery; injectable biomaterials; materials chemistry; rheology
Funding
- University of Notre Dame Advancing our Vision initiative
- American Cancer Society [IRG-14-195-01]
- Helmsley Charitable Trust
- Notre Dame Advanced Diagnostics and Therapeutics
- Notre Dame Center for Nanoscience and Technology
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Hydrogel biomaterials are pervasive in biomedical use. Applications of these soft materials range from contact lenses to drug depots to scaffolds for transplanted cells. A subset of hydrogels is prepared from physical cross-linking mediated by host-guest interactions. Host macrocycles, the most recognizable supramolecular motif, facilitate complex formation with an array of guests by inclusion in their portal. Commonly, an appended macrocycle forms a complex with appended guests on another polymer chain. The formation of poly(pseudo)rotaxanes is also demonstrated, wherein macrocycles are threaded by a polymer chain to give rise to physical cross-linking by secondary non-covalent interactions or polymer jamming. Host-guest supramolecular hydrogels lend themselves to a variety of applications resulting from their dynamic properties that arise from non-covalent supramolecular interactions, as well as engineered responsiveness to external stimuli. These are thus an exciting new class of materials.
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