Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 46, Pages 31558-31566Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b10166
Keywords
multifunctional nanoparticles; gold nanorods; gene therapy; photoacoustic imaging; photothermal therapy
Funding
- National Natural Science Foundation of China [51303173, 51233004, 51390484, 21474104, 51473029, 51403205, 51503200, 51520105004]
- Ten thousand talent program outstanding young scholars, Jilin province science and technology development program [20160204032GX]
- Fundamental Research Funds for the Central Universities [2412016KJ042]
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Multifunctional nanoparticles with high gene transfection activity, low cytotoxicity, photoacoustic imaging ability, and photothermal therapeutic properties were prepared by conjugating low-molecular-weight polyethylenimine onto the surfaces of gold nanorods through the formation of stable S-Au bonded conjugates. Results revealed that the gene transfection efficiency of the prepared polyethylenimine-modified gold nanorods (GNRs-PEI1.8k) was higher and their cytotoxicity was less than those of the commercial reagent PEI25k. GNRs-PEI1.8k could also be potentially used as a photoacoustic and photothermal reagent to evaluate the pharmacokinetics, biodistribution, and antitumor effects of gene/drug nanoparticles. Therefore, GNRs-PEI1.8k can be considered a promising candidate for the clinical diagnosis and treatment of tumors.
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