Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 15, Pages 9552-9556Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b01829
Keywords
boronic acid; hybrid particle; polymer branches; thiol-ene click reaction; glycoprotein
Funding
- National Natural Science Foundation of China [21375128, 21321064, 21575143]
- Ministry of Science and Technology of China [2012CB910601, 2012AA020202, 2013CB911201]
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A novel organic inorganic hybrid particle with high hydrophilicity three-dimensional boronic acid functional polymer branches was facilely synthesized through thiol-ene surface-initiated click reaction, by which the target glycoprotein could be captured selectively in the 5000-fold disrupting protein. This highest selectivity ever reported demonstrated that this boronic acid functionalized particle exhibited great potential in the recognition of cis-diol-containing biomolecules, including the glycoproteins.
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