Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 35, Pages 22860-22868Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b06488
Keywords
sensing heart disease; myoglobin; aptamer; 2-D materials; black phosphorus
Funding
- INST PDF
- CSIR-JRF
- DST, Government of India
- Parker family
- EPSRC [EP/K009710/1, EP/M010619/1]
- defense threat reduction agency [HDTRA1-12-1-0013]
- U.K. Engineering and Physical Sciences Research Council (EPSRC Core Capability in Chemistry, EPSRC) [EP/K039547/1]
- Engineering and Physical Sciences Research Council [EP/M010619/1, 1234280, EP/K009710/1, EP/K039547/1] Funding Source: researchfish
- EPSRC [EP/K039547/1, EP/M010619/1, EP/K009710/1] Funding Source: UKRI
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We report the electrochemical detection of the redox active cardiac biomarker myoglobin (Mb) using aptamer-functionalized black phosphorus nanostructured electrodes by measuring direct electron transfer. The as synthesized few-layer black phosphorus nanosheets have been functionalized with poly-L-lysine (PLL) to facilitate binding with generated anti-Mb DNA aptamers on nanostructured electrodes. This aptasensor platform has a record-low detection limit (similar to 0.524 pg mL(-1)) and sensitivity (36 mu A pg(-1) mL cm(-2)) toward Mb with a dynamic response range from 1 pg mL(-1) to 16 mu g mL(-1) for Mb in serum samples. This strategy opens up avenues to bedside technologies for multiplexed diagnosis of cardiovascular diseases in complex human samples.
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