Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 28, Pages 17842-17858Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b05038
Keywords
Mg-Zn-Y-Nd alloy; surface modification; in vitro degradation; biocompatibility; coronary artery stent
Funding
- National Basic Research Program of China [2012CB619102]
- Shenzhen Special Funds for Development of Strategic Emerging Industries [JCYJ20130402172114948]
- Shenzhen Science & Technology Developing Funding Project [CXZZ20140731091722497, CXZZ20140419114548507]
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Bioabsorbable magnesium alloys are becoming prominent as temporary functional implants, as they avoid the risks generated by permanent metallic implants such as persistent inflammation and late restenosis. Nevertheless, the overfast corrosion of Mg alloys under physiological conditions hinders their wider application as medical implant materials. Here we investigate a simple one-step process to introduce a cross-linked 3-amino-propyltrimethoxysilane (APTES) silane physical barrier layer on the surface of Mg-Zn-Y-Nd alloys prior to electrostatic spraying with rapamycin-eluting poly (lactic -co-glycolic acid) (PLGA) layer. Surface microstructure was characterized by scanning electron microscope and Fourier transform infrared spectroscopy. Nanoscratch test verified the superior adhesion strength of PLGA coating in the group pretreated with APTES. Electrochemical tests combined with long-term immersion results suggested that the preferable in vitro anticorrosion behavior could be achieved by dense APTES barrier. Cell morphology and proliferation data demonstrated that APTES pretreated group resulted in remarkably preferable compatibility for both human umbilical vein endothelial cells and vascular smooth muscle cells. On the basis of excellent in vitro mechenical property, the animal study on the APTES pretreated Mg-Zn-Y-Nd stent implanted into porcine coronary arteries confirmed benign tissue compatibility as well as re-endothelialization without thrombogenesis or in-stent restenosis at six-month followup.
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