Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 19, Pages 12039-12047Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b02721
Keywords
near-infrared absorption; theranostic nanoparticles; lysosome-targeting; photoacoustic imaging; photodynamic therapy
Funding
- National Basic Research Program of China [2012CB933301, 2012CB723402]
- National Natural Science Foundation of China [21574064, 51173080, 61378081, 51503103, 61136003, 21222404]
- Synergetic Innovation Center for Organic Electronics and Information Displays
- Natural Science Foundation of Jiangsu Province of China [BZ2010043, BM2012010, NY211003]
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Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and add-activatable PDT against cancer cells under NIR light.
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