Journal
LANCET
Volume 392, Issue 10161, Pages 2299-2312Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0140-6736(18)31948-2
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Funding
- Australian Rotary Health
- National Institute of Mental Health
- National Health and Medical Research Council
- New South Wales Ministry of Health
- Ramsay Health
- University of Sydney
- AstraZeneca
- Eli Lilly Co
- Organon
- Pfizer
- Servier
- Wyeth
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Major depression is a common illness that severely limits psychosocial functioning and diminishes quality of life. In 2008, WHO ranked major depression as the third cause of burden of disease worldwide and projected that the disease will rank first by 2030.1 In practice, its detection, diagnosis, and management often pose challenges for clinicians because of its various presentations, unpredictable course and prognosis, and variable response to treatment.
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