Expanding the spectrum of APOL1-related renal disease: de novo collapsing glomerulopathy following kidney transplant

Santoriello et al. report a series of 38 cases of de novo collapsing glomerulopathy following kidney transplant. Associations included acute rejection, viral infection, and APOL1 high-risk genotype (the latter in 9 cases). Risk factors for collapsing glomerulopathy included acute rejection, viral infection, acute vaso-occlusive disease, and an African American donor. The data are suggestive of, but do not directly establish, a role for interferon in these associations. Published by Elsevier, Inc., on behalf of the International Society of Nephrology.