Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Volume 1847, Issue 10, Pages 1166-1172Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbabio.2015.06.010
Keywords
V-ATPase; Wnt; mTOR; Notch; Signaling pathway
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Individual Research Grants in Doshisha Women's College of Liberal Arts [14-8]
- Grants-in-Aid for Scientific Research [25650066, 26291041] Funding Source: KAKEN
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The vacuolarli H+-ATPase (V-ATPase) was first identified as an electrogenic proton pump that acidifies the lumen of intra- and extracellular compartments. The acidic pH generated by V-ATPase is important for a wide range of cellular processes as well as acidification-independent processes such as secretion and membrane fusion. In addition to these housekeeping functions, recent studies implicate V-ATPase in the direct regulation and function of signaling pathways. In this review, we describe recent findings on the functions of V-ATPase in growth regulation and tissue physiology. (C) 2015 Elsevier B.V. All rights reserved.
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