Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 2, Pages 1406-1414Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b10617
Keywords
multimodal imaging; fluorescence imaging; magnetic resonance imaging; bioimaging; nanohybrids; iron oxide nanoparticles
Funding
- Spanish Ministry of Economy and Competitiveness [MAT2013-47395-C4-1-R, MAT2013-47395-C4-3-R]
- Madrid Regional Government [NANOFRONTMAG-CM S2013/MIT-2850]
- Spanish Ministry [FJCI-2014-21101]
- Universidad Autonoma de Madrid
- Ramon y Cajal subprogram [RYC-2011-09617]
- European COST action [TD1402]
- COST Actions [CM1006, CM1403]
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Breakthroughs in nanotechnology have made it possible to integrate different nanoparticles in one single hybrid nanostructure (HNS), constituting multifunctional nanosized sensors, carriers, and probes with great potential in the life sciences. In addition, such nanostructures could also offer therapeutic capabilities to achieve a wider variety of multifunctionalities. In this work, the encapsulation of both magnetic and infrared emitting nanoparticles into a polymeric matrix leads to a magnetic-fluorescent HNS with multimodal magnetic-fluorescent imaging abilities. The magnetic-fluorescent HNS are capable of simultaneous magnetic resonance imaging and deep tissue infrared fluorescence imaging, overcoming the tissue penetration limits of classical visible-light based optical imaging as reported here in living mice. Additionally, their applicability for magnetic heating in potential hyperthermia treatments is assessed.
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