Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 12, Pages 7657-7665Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b12645
Keywords
enzymes; mesoporous silica; delivery; nanoparticles; esterase; neoglycoenzyme; glucose
Funding
- Spanish Ministry of Science and Innovation [CTQ2011-24355, CTQ2009-12650, CTQ2009-09351, MAT2012-38429-004-01]
- Comunidad de Madrid [S2009/PPQ-1642]
- Generalitat Valencia [PROMETEOII/2014/047]
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We report herein the design of a stimulus-programmed pulsatile delivery system for sequential cargo release based on the use of a lactose-modified esterase as a capping agent in phenylboronic acid functionalized mesoporous silica nanoparticles. The dual-release Mechanism was based on the distinct stability of the cyclic boronic acid esters formed with lactose residues and the long naturally Occurring glycosylation chains in the modified neoglycoenzyme. Cargo delivery in succession was achieved using glucose and ethyl butyrate as triggers.
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