Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 16, Pages 10524-10534Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b01277
Keywords
microcapsulesc; chitosan; PLGA; nanoparticles; programmed sequential drug release
Funding
- National Natural Science Foundation of China [21322605, 21276002, 81321002]
- Training Program of Sichuan Province Distinguished Youth Academic and Technology Leaders [2013JQ0035]
- State Key Laboratory of Polymer Materials Engineering [sklpme2014-3-02]
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A novel type of core shell chitosan micro capsule with programmed sequential drug release is developed by the microfluidic technique for acute gastrosis therapy. The microcapsule is composed of a cross-linked chitosan hydrogel shell and an oily core containing both free drug molecules and drug-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles. Before exposure to acid stimulus, the resultant microcapsules can keep their structural integrity without leakage of the encapsulated substances. Upon acid-triggering, the microcapsules first achieve burst release due to the acid-induced decomposition of the chitosan shell. The encapsulated free drug molecules and drug-loaded PLGA nanoparticles are rapidly released within 60 s. Next, the drugs loaded in the PLGA nanoparticles are slowly released for several days to achieve sustained release based on the synergistic effect of drug diffusion and PLGA degradation. Such core shell chitosan microcapsules with programmed sequential drug release are promising for rational drug delivery and controlled-release for the treatment of acute gastritis. In addition, the microcapsule systems with programmed sequential release provide more versatility for controlled release in biomedical applications.
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