Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 16, Pages 10128-10135Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b00145
Keywords
nitric oxide; transition metal; S-nitrosothiol; biodegradable stent; thrombosis
Funding
- National Science Foundation-Division of Materials Research Grant [1410192]
- National Institutes of Health [R15HL113954]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1410192] Funding Source: National Science Foundation
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Nitric oxide (NO), identified over the last several decades in many physiological processes and pathways as both a beneficial and detrimental signaling molecule, has been the subject of extensive research. Physiologically, NO is transported by a class of donors known as S-nitrosothiols. Both endogenous and synthetic S-nitrosothiols have been reported to release NO during interactions with certain transition metals, primarily Cu2+ and Fe2+. Ag+ and Hg2+ have also been identified, although these metals are not abundantly present in physiological systems. Here, we evaluate Pt2+, Fe2+, Fe2+, Mg2+, Zn2+, Mn2+, Co2+, Ni2+, and Cu2+ for their ability to generate NO from S-nitroso-N-acetyl-D-penicillamine (SNAP) under physiological pH conditions. Specifically, we report NO generation from RSNOs initiated by three transition metal ions; Co2+, Ni2+, and Zn2+, which have not been previously reported to generate NO. Additionally, preliminary in vivo evidence of zinc wires implanted in the rat arterial wall and circulating blood is presented which demonstrated inhibited thrombus formation after 6 months. One potentially useful application of these metal ions capable of generating NO from RSNOs is their use in the fabrication of biodegradable metallic stents capable of generating NO at the stent-blood interface, thereby reducing stent-related thrombosis and restenosis.
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