Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 43, Pages 29232-29241Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b06883
Keywords
gold nanospheres; indocyanine green; computed tomography; NIR fluorescence imaging; photothermal therapy; imaging-guided therapy
Funding
- National Natural Science Foundation of China [81227901, 81501540, 61231004, U1401254, 61401462, 61501462, 81527805, 81470083]
- National High Technology Research and Development Program of China (863 Program) [2012AA021105]
- Guangdong provincial science and technology plan projects [2014A020212647]
- Cultivation of Guangdong College Students' Scientific and Technological Innovation project (Climbing Program Special Funds) [pdjh2016b0103, pdjh2016a0090]
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To improve patient outcome and decrease overall health-care costs, highly sensitive and precise detection of a tumor is required for its accurate diagnosis and efficient therapy; however, this remains a challenge when using conventional single mode imaging. Here, we successfully designed a near infrared (NIR)-response photothermal therapy (PTT) platform (Au@MSNs-ICG) for the location, diagnosis, and NIR/computer tomography (CT) bimodal imaging-guided PTT of tumor tissues, using gold (Au) nanospheres coated with indocyanine green (ICG)-loaded mesoporous silica nanoparticles (MSNs), which would have high sensitivity and precision. The nanoparticles (NPs) exhibited good monodispersity, fluorescence stability, biocompatibility, and NIR/CT signaling and had a preferable temperature response under MR laser irradiation in vitro or in vivo. Using a combination of NIR/CT imaging and PTT treatment, the tumor could be accurately positioned and thoroughly eradicated in vivo by Au@MSNs-ICG injection. Hence, the multifunctional NPs could play an important role in facilitating the accurate treatment of tumors in future clinical applications.
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