Journal
JOURNAL OF ULTRASOUND IN MEDICINE
Volume 38, Issue 3, Pages 567-580Publisher
WILEY
DOI: 10.1002/jum.14733
Keywords
cancer; cavitation; clinical translation; sonodynamic therapy; ultrasound
Funding
- Japan Society for the Promotion of Science [PE16053]
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Sonodynamic therapy (SDT) consists of the synergetic interaction between ultrasound and a chemical agent. In SDT, the cytotoxicity is triggered by ultrasonic stimuli, notably through cavitation. The unique features of SDT are relevant in the clinical context more than ever: the need for efficacy, accuracy, and safety while being noninvasive and preserving the patient's quality of life. However, despite the promising results of this technique, only a few clinical reports describe the use of SDT. The objective of this article is to provide an extensive overview of the clinical and preclinical research conducted in vivo on SDT, to identify the limitations, and to detail the developed strategies to overcome them.
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