Journal
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
Volume 51, Issue -, Pages 212-218Publisher
ELSEVIER GMBH
DOI: 10.1016/j.jtemb.2018.10.021
Keywords
Gadolinium retention; NSF; LA-ICP-MS; ICP-MS/MS; Quantitative bioimaging
Funding
- UA-DAAD collaboration grant
- Australian Research Council Discovery Project [DP170100036]
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A novel analytical method to detect the retention of gadolinium from contrast agents for magnetic resonance imaging (MRI) in tissue samples of patients is presented. It is based on laser ablation - inductively coupled plasma - triple quadrupole - mass spectrometry (LA-ICP-MS/MS). Both Gd and P were monitored with a mass shift of + 16, corresponding to mono-oxygenated species, as well as Zn, Ca, and Fe on-mass. This method resulted in a significantly reduced background and improved limits of detection not only for phosphorus, but also for gadolinium. These improvements were essential to perform elemental bioimaging with improved resolution of 5 mu m x 5 mu m, allowing the detection of small Gd deposits in fibrotic skin and brain tumour tissue with diameters of approximately 50 mu m. Detailed analyses of these regions revealed that most Gd was accompanied with P and Ca, indicating co-precipitation.
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