Journal
JOURNAL OF THEORETICAL BIOLOGY
Volume 461, Issue -, Pages 239-253Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2018.10.040
Keywords
Indirect transfers; Kinetic; Quasi-linear equation; Population dynamics models
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The efflux protein P-glycoprotein (P-gp) is over expressed in many cancer cells and has a known capacity to confer multi-drug resistance to cytotoxic therapies. We provide a mathematical model for the direct cell-to-cell transfer of proteins between cells and the indirect transfer between cells and the surrounding liquid. After a mathematical analysis of the model, we construct an adapted numerical scheme and give some numerical simulations. We observe that we obtain a better fit with the experimental data when we take into account the indirect transfer of the protein released in a dish. This quantity, usually neglected by the experimenters, seems to influence the results. (C) 2018 Elsevier Ltd. All rights reserved.
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