Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 45, Pages 30780-30787Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b10986
Keywords
biomaterials; PDMS; silicone; bacteria; polymers; Pseudomonas; catheter
Funding
- Wellcome Trust [103882, 103884]
- Engineering and Physical Sciences Research Council [EP/K005139/1]
- Engineering and Physical Sciences Research Council [EP/N006615/1] Funding Source: researchfish
- Wellcome Trust [103882/Z/14/Z] Funding Source: researchfish
- EPSRC [EP/N006615/1] Funding Source: UKRI
- Wellcome Trust [103882/Z/14/Z] Funding Source: Wellcome Trust
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Biomedical devices are indispensable in modern medicine yet offer surfaces that promote bacterial attachment and biofilm formation, resulting in acute and chronic healthcare associated infections. We have developed a simple method to graft acrylates to silicone rubber, polydimethylsiloxane (PDMS), a commonly used device material that is often colonized by bacteria. We demonstrate a novel method whereby nontoxic bacteria attachment-resistant polymers can be readily grafted from and grafted to the surface using thiol-ene chemistry, substantially reducing bacterial colonization. With use of this approach, bacterial biofilm coverage can be reduced by 99% compared with standard PDMS in an in vitro assay. This grafting approach offers significant advantages over commonly used physisorbed coatings, especially in areas of high shear or mechanical stress. Furthermore, the approach is versatile such that the grafted material properties can be tailored for the desired final application.
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