Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 18, Pages 11246-11254Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b12848
Keywords
fullerene; macromolecular MRI contrast agent; contrast enhancement; tumor-targeting imaging; low toxicity
Funding
- National Natural Science Foundation of China [51372251, 51502301]
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A macromolecular magnetic resonance imaging (MRI) contrast agent was successfully synthesized by conjugating the gadolinium/1,4,7,10-tetraazacydododecane-1,4,7-tetracetic acid complex (Gd-DO3A) with 6,6-phenyl-C-61 butyric acid (PC(61)BA) and upon further modification with human serum albumin (HSA). The final product, PC(61)BA-(Gd-DO3A)/HSA, has a high stability and exhibits a much higher relaxivity (r(1) = 89.1 mM(-1) s(-1) at 0.5 T, 300 K) than Gd-DO3A (r(1) = 4.7 mM(-1) s(-1)) does under the same condition, producing the synergistic positive effect of HSA and C-60 on the relaxivity of Gd-DO3A. The in vivo MR images of PC(61)BA-(Gd-DO3A)/HSA-treated tumor-bearing mice show strong signal enhancement for the tumor area due to the enhanced permeability and retention effect. The maximum accumulation of PC(61)BA-(Gd-DO3A)/HSA at the tumor site was achieved at 4 h postinjection, which may guide surgery. The results from the hematology and histological observations indicate that PC(61)BA-(Gd-DO3A)/HSA has no obvious toxicity in vivo. These unique properties of PC(61)BA-(Gd-DO3A)/HSA enable them to be highly efficient for tumor-targeting MRI in vivo, possibly providing a good solution for tumor diagnosis.
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