Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 140, Issue 51, Pages 17992-17998Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b09580
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Funding
- NSFC/China [21472044, 21425311, 21790361, 21421004]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX03]
- Fundamental Research Funds for the Central Universities [222201717003]
- Program of Introducing Talents of Discipline to Universities [B16017]
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Inspired by natural biomolecular machines, synthetic molecular-level machines have been proven to perform well-defined mechanical tasks and measurable work. To mimic the function of channel proteins, we herein report the development of a synthetic molecular shuttle, [2]rotaxane 3, as a unimolecular vehicle that can be inserted into lipid bilayers to perform passive ion transport through its stochastic shuttling motion. The [2]rotaxane molecular shuttle is composed of an amphiphilic molecular thread with three binding stations, which is interlocked in a macrocycle wheel component that tethers a K+ carrier. The structural characteristics enable the rotaxane to transport ions across the lipid bilayers, similar to a cable car, transporting K+ with an EC50 value of 1.0 mu M (3.0 mol % relative to lipid). We expect that this simple molecular machine will provide new opportunities for developing more effective and selective ion transporters.
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