Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 140, Issue 49, Pages 16914-16919Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b10766
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Funding
- National Natural Science Foundation of China [21672098, 21732003]
- National Key Research and Development Program of China [2018YFC0310900]
- Fundamental Research Funds for the Central Universities [020814380092]
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Highly regio- and enantioselective allylic alkylation has been achieved enabled by the merger of photoredox and palladium catalysis. In this dual catalytic process, alkyl radicals generated from 4-alkyl-1,4-dihydropyridines act as the coupling partners of the pi-allyl palladium complexes. The generality of this method has been illustrated through the reaction of a variety of allyl esters with 4-alkyl-1,4-dihydropyridines. This mechanistically novel strategy expands the scope of the traditional Pd-catalyzed asymmetric allylic alkylation reaction and serves as its alternative and potential complement.
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