Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 141, Issue 3, Pages 1366-1372Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b12167
Keywords
-
Categories
Funding
- Korean government (MSIP) [2012R1A3A2048814]
- National Natural Science Foundation of China [U1705282, 21473033]
- Korea Mouse Phenotyping Project of the National Research Foundation [NRF-2016M3A9D5A01952416]
- Ministry of Food and Drug Safety [14182MFDS978]
- Brain Korea 21 PLUS Project for Medical Science, Yonsei University
- National Research Foundation of Korea (NRF) grants - Korean government (MSIT) [2018R1A5A2025286, NRF-2017R1A2B4010084]
Ask authors/readers for more resources
Albumin is a promising candidate as a biomarker for potential disease diagnostics and has been extensively used as a drug delivery carrier for decades. In these two directions, many albumin-detecting probes and exogenous albumin-based nano composite delivery systems have been developed. However, there are only a few cases demonstrating the specific interactions of exogenous probes with albumin in vivo, and nanocomposite delivery systems usually suffer from tedious fabrication processes and potential toxicity of the complexes. Herein, we demonstrate a facile one-for-all switchable nanotheranostic (NanoPcS) for both albumin detection and cancer treatment. In particular, the in vivo specific binding between albumin and PcS, arising from the disassembly of injected NanoPcS, is confirmed using an inducible transgenic mouse system. Fluorescence imaging and antitumor tests on different tumor models suggest that NanoPcS has superior tumor-targeting ability and the potential for time-modulated, activatable photodynamic therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available