Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 140, Issue 43, Pages 14267-14271Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b08457
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Funding
- EPSRC
- EPSRC [EP/R003939/1]
- Royal Society
- National Natural Science Foundation of China [21788102, 21722801, 21572058]
- Programme of Introducing Talents of Discipline to Universities [B16017]
- Shanghai Rising-Star Program [16QA1401400]
- Robert A. Welch Foundation [F-0018]
- University of Bath
- EPSRC [1792244] Funding Source: UKRI
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A series of 3-hydroxyflavone (3-HF) ESIPT (excited-state intramolecular proton transfer) boronate-based fluorescent probes have been developed for the detection of peroxynitrite (ONOO-). The dyes are environmentally sensitive, and each probe exhibited a ratiometric response toward ONOO- in a micellar environment. The probes were used to image different aggregation states of amyloid-beta (A beta) in the presence of ONOO-. The 3-HF-OMe probe was found to produce a ratiometric response toward ONOO- when bound to A beta aggregates, resulting in a novel host-guest ensemble, which adds insight into the development of other ESIPT-based probes for the simultaneous sensing of fibrous proteins/peptides and environmental ROS/RNS.
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