Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 7, Pages 4407-4415Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b10885
Keywords
Janus capsule; leukocyte cell; biocompatible; target recognition; phagocytosis
Funding
- National Nature Science Foundation of China [21573053, 21503058]
- HIT for the startup grant
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Modern drug delivery systems rely on either antibody-based single-surface recognition or on surface-hydrophobicity-based approaches. For a tumor showing various surface mutations, both approaches fail. This publication hereby presents Janus capsules based on polyelectrolyte multilayer microcapsules exhibiting human leucocyte (THP-1 cell line) cell membranes for discriminating HUVEC cells from three different cancer cell lines. Despite destroying the cellular integrity of leucocyte cells, the modified Janus capsules are able to adhere to cancer cells. Leucocyte cell-membrane-coated Janus capsules are phagocytosed with the cellular membrane part pointing to the cells.
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