Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 141, Issue 6, Pages 2348-2355Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b10302
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Funding
- Australian Research Council [DP170103531]
- National Natural Science Foundation of China [21571037]
- Australian Government Research Training Program Scholarships
- Australian Government
- CERIC ERIC consortium [20182161]
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Encapsulation of biomacromolecules in metal-organic frameworks (MOFs) can preserve biological functionality in harsh environments. Despite the success of this approach, termed biomimietic mineralization, limited consideration has been given to the chemistry of the MOF coating. Here, we show that enzymes encapsulated within hydrophilic MAF-7 or ZIF-90 retain enzymatic activity upon encapsulation and when exposed to high temperatures, denaturing or proteolytic agents, and organic solvents, whereas hydrophobic ZIF-8 affords inactive catalase and negligible protection to urease.
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